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All Journal Bionatura Jurnal Farmasi Sains dan Komunitas (JFSK) JURNAL ILMU KEFARMASIAN INDONESIA Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat

Yohanes Dwiatmaka

Universitas Sanata Dharma

Author-ID : 256708

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Medicine & Pharmacology Social Sciences Other

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PENETAPAN KANDUNGAN FENOLAT TOTAL DAN UJI AKTIVITAS ANTIOKSIDAN MENGGUNAKAN RADIKAL DPPH FRAKSI ETIL ASETAT SARI BUAH APEL BELUDRU (Diospyros blancoi A. DC.) Johannes Baptista Yunio Rahmawan; Yohanes Dwiatmaka
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 10, No 2 (2013)
Publisher : Sanata Dharma University

Abstract: Antioxidant plays a role in inhibiting oxidation by binding to free radicals. As a result,the cell damage that leads to degenerative diseases can be inhibited. This research wasconducted to determine the antioxidant activity and total phenolic content of ethyl acetatefraction of velvet aple (Diospyros blancoi A.DC.) juice. Previously known that other plants fromgenus Diospyros contain phenolic compounds such as quercetin. Antioxidant activity testperformed qualitatively and quantitatively using radical of 1,1-diphenyl-2 pikrilhidrazil(DPPH) and expressed as the value Inhibition Concentration 50 (IC50). Determination of totalphenolic using Folin-Ciocalteu method expressed as equivalent mass of gallic acid. Phenoliccompounds will be oxidized by the Folin-Ciocalteu under alkaline conditions, forming a bluesolution. The results showed that the ethyl acetate fraction of velvet apple juice has very strongantioxidant activity with IC50 of (30.0 0.09) mg / mL. Total phenolic content of (393.5 0.35) mggallic acid equivalents per gram of ethyl acetate fraction.Keywords: antioxidant, velvet apple (Diospyros blancoi A. DC), ethyl acetate fraction, DPPH,total phenolic content.

EFEK SITOTOKSIK EKSTRAK DIETIL ETER HERBA PEGAGAN EMBUN (Hydrocotyle sibthorpioides Lmk.) TERHADAP SEL KANKER PAYUDARA MCF-7 Agustina Setiawati; Yohanes Dwiatmaka
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 12, No 1 (2015)
Publisher : Sanata Dharma University

Abstract: Triterpenoid saponin, hydrocosaponin A-F, isolated compound from Hydrocotyle sibthorpioides Lmk. performed cytotoxic activity on KB, Daoy and WiDr cancer cells. Methanolic extract of this herb was also investigated in inhibiting cancer development on liver and cervical cancer. Therefore, it is potential to be developed as chemopreventive agent. The objective of this study is to determine cytotoxic activity and compound in diethyl ether extract of Hydrocotyle sibthorpioides Lmk. herbs. The cytotoxic effect of extract on MCF-7 breast cancer cell line was assayed using MTT method while phytochemical analysis was observed using normal phase Thin Layer Chromatoraphy (TLC). Diethyl ether extract of Hydrocotyle sibthorpioides had cytotoxic effect on MCF-7 cells with IC50 365 g/mL. TLC analysis observed that the extract contain flavonoid compounds. Keywords : Hydrocotyle sibthorpioides, MCF-7, cytotoxic, flavonoid

Co-Authors Agatha Budi Susiana Lestari Agustina Setiawati Fransiscus Asisi Joko Siswanto Johannes Baptista Yunio Rahmawan Lestari, A B S - Rubiyatno Rubiyatno Rubiyatno Rubiyatno Susanti, L U -

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Journal : Jurnal Farmasi Sains dan Komunitas (JFSK)